Good Clinical Outcome After Accidental Intra-arterial Injection of Flunitrazepam Tablets in 16 Drug Abusers with Critical Limb Ischaemia

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Good clinical outcome after accidental intra-arterial injection of flunitrazepam tablets in 16 drug abusers with critical limb ischaemia.

OBJECTIVES Inadvertent intra-arterial injection of flunitrazepam tablets intended for intravenous use by drug abusers has devastating effects. We report here on the clinical outcome of 16 drug abusers developing critical limb ischaemia after flunitrazepam injection. METHODS Treatment combined immediate analgesia and anticoagulation, long-lasting local thrombolysis and vasodilatation, antibiot...

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Accidental intra-arterial injection.

Accidental intra-arterial injection of intramuscular antibiotic preparations is described in 3 cases in infants. In 2 benzathine penicillin was injected, and in 1 rolitetracycline. The clinical features are dominated by arteriolar obstruction which produces gangrene of the most severely affected limb. In addition, neuroloigcal involvement occurs when vessels to nerves or spinal cord are involve...

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Limb ischaemia after intra-arterial injection of Temazepam gel: histology of nine cases.

AIMS To record the histopathological findings associated with intra-arterial injection of Temazepam gel by nine drug misusers. METHODS Standard histological examination and immunocytochemistry for endothelial markers (factor VIII related antigen, Ulex europaeus lectin) were carried out. RESULTS Intra-arterial injection of Temazepam gel may cause severe vascular injury and lead to amputation...

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Localized retiform purpura after accidental intra-arterial injection of polidocanol.

Sir, Non-inflammatory retiform (net-like or livedoid) purpura (NIRP) is a clinical pattern produced by small vessel occlusion in dermis. Several disorders such as coagulation abnormalities, cold-related gelling, microorganism vessel invasion or embolization leading to microvascular occlusion may share in common a clinical picture of localized or generalized NIRP (1). NIRP lesions are usually sh...

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Outcome and complications after intra-arterial thrombolysis for lower limb ischaemia with or without continuous heparin infusion

BACKGROUND Thrombolysis is a common treatment for acute leg ischaemia. The purpose of this study was to evaluate different thrombolytic treatment strategies, and risk factors for complications. METHODS This was a retrospective analysis of prospective databases from two vascular centres. One centre used a higher dose of heparin and recombinant tissue plasminogen activator (rtPA). RESULTS Som...

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ژورنال

عنوان ژورنال: Journal of Vascular Surgery

سال: 2014

ISSN: 0741-5214

DOI: 10.1016/j.jvs.2013.11.082